A survey of sub-inhibitory concentrations of antibiotics in the environment

LKM Chow, TM Ghaly, MR Gillings - Journal of Environmental Sciences, 2021 - Elsevier
Antibiotics are poorly metabolized, and can enter the environment via human waste streams,
agricultural run-off and pharmaceutical effluent. We consequently expect to see a …

The peril and promise of integrons: beyond antibiotic resistance

TM Ghaly, JL Geoghegan, SG Tetu, MR Gillings - Trends in microbiology, 2020 - cell.com
Integrons are bacterial genetic elements that can capture, rearrange, and express mobile
gene cassettes. They are best known for their role in disseminating antibiotic-resistance …

[HTML][HTML] Free-floating extracellular DNA: Systematic profiling of mobile genetic elements and antibiotic resistance from wastewater

D Calderón-Franco, MCM van Loosdrecht, T Abeel… - Water Research, 2021 - Elsevier
The free-floating extracellular DNA (exDNA) fraction of microbial ecosystems harbors
antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs). Natural …

[HTML][HTML] Environmental dissemination of carbapenemase-producing Enterobacteriaceae in rivers in Switzerland

S Bleichenbacher, MJA Stevens, K Zurfluh… - Environmental …, 2020 - Elsevier
The aquatic environment takes on a key role in the dissemination of antimicrobial-resistant
Enterobacteriaceae. This study assesses the occurrence of carbapenemase-producing …

[HTML][HTML] Upgrading residues from wastewater and drinking water treatment plants as low-cost adsorbents to remove extracellular DNA and microorganisms carrying …

D Calderón-Franco, S Apoorva, G Medema… - Science of the Total …, 2021 - Elsevier
Wastewater treatment is challenged by the continuous emergence of chemical and
biological contaminants. Disinfection, advanced oxidation, and activated carbon …

New perspectives on mobile genetic elements: a paradigm shift for managing the antibiotic resistance crisis

TM Ghaly, MR Gillings - Philosophical Transactions of the …, 2022 - royalsocietypublishing.org
Mobile genetic elements (MGEs) are primary facilitators in the global spread of antibiotic
resistance. Here, we present novel ecological and evolutionary perspectives to understand …

Genetic plurality of blaKPC-2-harboring plasmids in high-risk clones of Klebsiella pneumoniae of environmental origin

JPR Furlan, R da Silva Rosa, MS Ramos… - Science of The Total …, 2023 - Elsevier
International high-risk clones of Klebsiella pneumoniae are important human pathogens that
are spreading to the environment. In the COVID-19 pandemic scenario, the frequency of …

The effect of plastic-related compounds on transcriptome-wide gene expression on CYP2C19-overexpressing hepG2 cells

M Rosellini, A Schulze, EA Omer, NT Ali, F Marini… - Molecules, 2023 - mdpi.com
In recent years, plastic and especially microplastic in the oceans have caused huge
problems to marine flora and fauna. Recently, such particles have also been detected in …

A Novel Family of Acinetobacter Mega-Plasmids Are Disseminating Multi-Drug Resistance Across the Globe While Acquiring Location-Specific Accessory Genes

TM Ghaly, IT Paulsen, A Sajjad, SG Tetu… - Frontiers in …, 2020 - frontiersin.org
Acinetobacter species are emerging as major nosocomial pathogens, aided by their ability
to acquire resistance to all classes of antibiotics. A key factor leading to their multi-drug …

Responsible science, engineering and education for water resource recovery and circularity

DG Weissbrodt, MKH Winkler, GF Wells - … Science: Water Research & …, 2020 - pubs.rsc.org
Water resource recovery is central to the circular economy framework. It underlies the
transition of environmental engineering from pollution prevention to responsible innovation …