The cyclin D-CDK4/6 complexes play a pivotal role in controlling the cell cycle. Deregulation
in cyclin D-CDK4/6 pathway has been described in many types of cancer and it invariably …

Given their intrinsic pleiotropism, microRNAs (miR) play complex biological roles, in both
normal and pathological conditions. Often the same miR can act as oncogene or …

Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a
single dose during lumpectomy, can effectively replace postoperative whole breast external …

The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is
overexpressed in the majority of cancers and its activity strongly contributes to tumour …

Importance Conventional adjuvant radiotherapy for breast cancer given daily for several
weeks is onerous and expensive. Some patients may be obliged to choose a mastectomy …

Changes in the expression of microRNAs can affect cancer cells' viability and behavior and
the impact on cancer treatment. In this study, the expression of miR‐155‐5p, miR‐203a‐3p …

MicroRNAs (miRNAs) are mighty post-transcriptional regulators in cell physiology and
pathophysiology. In this review, we focus on the role of miR-223-3p (henceforth miR-223) in …

Abstract miR-223 is an anti-inflammatory miRNA that in cancer acts either as an
oncosuppressor or oncopromoter, in a context-dependent manner. In breast cancer, we …

MicroRNAs (miRNAs) constitute a large family of small, non-coding RNAs with the capacity
to regulate gene expression post-transcriptionally. miRNAs appear to hold promise of …

Intraoperative radiotherapy (IORT) for early stage breast cancer is a technique for partial
breast irradiation. There are several technologies in clinical use to perform breast IORT …