Major depressive disorder

W Marx, BWJH Penninx, M Solmi… - Nature Reviews …, 2023 - nature.com
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Major depressive disorder: hypothesis, mechanism, prevention and treatment

L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - Signal transduction and …, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

B Guo, M Zhang, W Hao, Y Wang, T Zhang… - Translational …, 2023 - nature.com
Mood disorders are associated with elevated inflammation, and the reduction of symptoms
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …

Frontostriatal salience network expansion in individuals in depression

CJ Lynch, IG Elbau, T Ng, A Ayaz, S Zhu, D Wolk… - Nature, 2024 - nature.com
Decades of neuroimaging studies have shown modest differences in brain structure and
connectivity in depression, hindering mechanistic insights or the identification of risk factors …

Prefrontal cortex and depression

DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022 - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Perspective of artificial intelligence in healthcare data management: A journey towards precision medicine

NS Gupta, P Kumar - Computers in biology and medicine, 2023 - Elsevier
Mounting evidence has highlighted the implementation of big data handling and
management in the healthcare industry to improve the clinical services. Various private and …

Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management

M Berk, O Köhler‐Forsberg, M Turner… - World …, 2023 - Wiley Online Library
Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Deep learning models reveal replicable, generalizable, and behaviorally relevant sex differences in human functional brain organization

S Ryali, Y Zhang, C de Los Angeles, K Supekar… - Proceedings of the …, 2024 - pnas.org
Sex plays a crucial role in human brain development, aging, and the manifestation of
psychiatric and neurological disorders. However, our understanding of sex differences in …

Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis

I Sezer, DA Pizzagalli, MD Sacchet - Neuroscience & Biobehavioral …, 2022 - Elsevier
This review synthesizes relations between mindfulness and resting-state fMRI functional
connectivity of brain networks. Mindfulness is characterized by present-moment awareness …

[HTML][HTML] Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology

DR Goldsmith, M Bekhbat, ND Mehta, JC Felger - Biological psychiatry, 2023 - Elsevier
Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …