Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

In recent years, chemical crosslinking of protein complexes and the identification of
crosslinked residues by mass spectrometry (XL-MS; sometimes abbreviated as CX-MS) has …

Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when
these amplify from a protein template, or seed, whose structure is unknown. We have …

Molecular docking is a computational method for predicting the placement of ligands in the
binding sites of their receptor (s). In this review, we discuss the methodological …

Cross-linking mass spectrometry (XL-MS) has received considerable interest, owing to its
potential to investigate protein–protein interactions (PPIs) in an unbiased fashion in complex …

Structural mass spectrometry (MS) is gaining increasing importance for deriving valuable
three‐dimensional structural information on proteins and protein complexes, and it …

Integrative structural biology attempts to model the structures of protein complexes that are
challenging or intractable by classical structural methods (due to size, dynamics, or …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

The study of proteins and protein complexes using chemical cross-linking followed by the
MS identification of the cross-linked peptides has found increasingly widespread use in …

Previously, we published an article providing an overview of the Rosetta suite of
biomacromolecular modeling software and a series of step-by-step tutorials [Kaufmann, KW …