Cancer is difficult to cure due to frequent metastasis, and develo** effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …

The discovery of microRNAs (miRNAs) almost two decades ago established a new
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …

Immune-checkpoint blockade has revolutionized cancer treatment, but some cancers, such
as acute myeloid leukemia (AML), do not respond or develop resistance. A potential mode of …

Ferroptosis, a form of regulated necrosis driven by iron-dependent peroxidation of
phospholipids, is regulated by cellular metabolism, redox homeostasis, and various …

Iron-mediated activation of peroxymonosulfate (PMS) has long been of a great interest for
the effective oxidation of micropollutants. In this study, ferroferric oxide doped powdered …

Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …

Immunotherapies that produce durable responses in some malignancies have failed in
pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor …

CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9 …

RNA-binding proteins (RBPs) are essential modulators of transcription and translation
frequently dysregulated in cancer. We systematically interrogated RBP dependencies in …

The adenomatous polyposis coli (APC) tumor suppressor is mutated in the vast majority of
human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine …