Each day, the human body eliminates billions of unwanted cells by apoptotic suicide.
Apoptosis provides an important barrier against cancer; however, specific mutations enable …

Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations
in human cancer. The majority of the mutations occur in the core domain which contains the …

Chemotherapy and radiation therapy for cancer often have severe side effects that limit their
efficacy. Because these effects are in part determined by p53-mediated apoptosis …

Abstract ALTHOUGH MOST PITUITARY tumors are well differentiated, histologically benign
neoplasms, their clinical behavior is known to vary greatly. These lesions are relentlessly …

Single cell biology has revealed that solid tumors and tumor-derived cell lines typically
contain subpopulations of cancer cells that are readily distinguishable from the bulk of …

Apoptosis, or programmed cell death, is defined by morphologic change resulting in
nonpathologic cell loss and is relevant to a wide spectrum of biology. The process is best …

Despite intense research, the 5‐year survival rate for patients with squamous cell carcinoma
of the head and neck (SCCHN) is still low. Several different factors have been studied in the …

The tumor suppressor protein, p53, is part of the cell's emergency team that is called upon
following cellular insult. How do cells sense DNA damage and other cellular stresses and …

PURPOSE The p53 gene encompasses 16 to 20 kb of DNA on the short arm of human
chromosome 17. It encodes for a 393-amino acid nuclear phosphoprotein involved in cell …

The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. Three
alternatively spliced transcripts of p33ING1 encode p47ING1a, p33ING1b, and p24ING1c …