Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

O Koniev, A Wagner - Chemical Society Reviews, 2015 - pubs.rsc.org
Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Rapid and efficient protein synthesis through expansion of the native chemical ligation concept

SS Kulkarni, J Sayers, B Premdjee… - Nature Reviews …, 2018 - nature.com
The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

Peptide coupling reagents, more than a letter soup

A El-Faham, F Albericio - Chemical reviews, 2011 - ACS Publications
In recent years, peptide-coupling reactions have significantly advanced in parallel with the
development of new peptidecoupling reagents, which have been covered in a number of …

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

W Tang, ML Becker - Chemical Society Reviews, 2014 - pubs.rsc.org
Peptides that comprise the functional subunits of proteins have been conjugated to versatile
materials (biomolecules, polymers, surfaces and nanoparticles) in an effort to modulate cell …

Nanopore analytics: sensing of single molecules

S Howorka, Z Siwy - Chemical Society Reviews, 2009 - pubs.rsc.org
In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …

Total chemical synthesis of proteins

SBH Kent - Chemical Society Reviews, 2009 - pubs.rsc.org
This tutorial review outlines the modern ligation methods that enable the efficient total
chemical synthesis of enzymes and other protein molecules. Key to this success is the …

Chemical protein synthesis: advances, challenges, and outlooks

Y Tan, H Wu, T Wei, X Li - Journal of the American Chemical …, 2020 - ACS Publications
Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

Glycoprotein synthesis: an update

DP Gamblin, EM Scanlan, BG Davis - Chemical reviews, 2009 - ACS Publications
1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

Antifungal plant defensins: mechanisms of action and production

K Vriens, BPA Cammue, K Thevissen - Molecules, 2014 - mdpi.com
Plant defensins are small, cysteine-rich peptides that possess biological activity towards a
broad range of organisms. Their activity is primarily directed against fungi, but bactericidal …