Molecular glue degraders: exciting opportunities for novel drug discovery
T Lemaitre, M Cornu, F Schwalen, M Since… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Molecular Glue Degraders (MGDs) is a concept that refers to a
class of compounds that facilitate the interaction between two proteins or molecules within a …
class of compounds that facilitate the interaction between two proteins or molecules within a …
In silico modeling of targeted protein degradation
Targeted protein degradation (TPD) techniques, particularly proteolysis-targeting chimeras
(PROTAC) and molecular glue degraders (MGD), have offered novel strategies in drug …
(PROTAC) and molecular glue degraders (MGD), have offered novel strategies in drug …
[HTML][HTML] New insights into the dule roles CDK12 in human cancers: mechanisms and interventions for cancer therapy
W Dai, D **e, H Huang, J Li, C Guo, F Cao… - Journal of …, 2024 - Elsevier
The dysregulation of cyclin-dependent kinase 12 (CDK12), which may result from genomic
alterations or modulation by upstream effectors, is implicated in cancer oncogenesis and …
alterations or modulation by upstream effectors, is implicated in cancer oncogenesis and …
Discovery of 4-(2-(methylamino) thiazol-5-yl) pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal …
Y Cao, S Huang, Y He, Y Zhang, S Chen, M Huang… - Bioorganic …, 2025 - Elsevier
The transcriptional cyclin-dependent protein kinase 12 (CDK12), a potential target in various
cancers, was recently discovered with a dramatic amplification in esophageal cancer (EC) …
cancers, was recently discovered with a dramatic amplification in esophageal cancer (EC) …
Small molecule targeted protein degradation via the UPS: venturing beyond E3 substrate receptors
R Guo, F Yang, EC Cherney - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
The ubiquitin proteasome system (UPS) has been successfully hi-jacked by both
bifunctional and monovalent small molecules to affect the degradation of proteins that were …
bifunctional and monovalent small molecules to affect the degradation of proteins that were …
Advances in Structural Types and Pharmacochemistry of CDK12 Inhibitors
D Wang, M **a, J Yan, L Yu, S Li - Medicinal Chemistry, 2025 - benthamdirect.com
Cyclin-Dependent Kinase (CDK) 12 is a member of the 20-membered CDK family (CDK1-
20) and plays a vital role in regulating gene transcription, mRNA splicing, translation, cell …
20) and plays a vital role in regulating gene transcription, mRNA splicing, translation, cell …
[HTML][HTML] MYCN in neuroblastoma: the kings' new clothes and drugs
M Müller, K Trunk, D Fleischhauer, G Büchel - EJC Paediatric Oncology, 2024 - Elsevier
Deregulated levels of the MYCN oncogene contribute to the tumorigenesis of several human
tumors including neuroblastoma. MYCN amplification classifies neuroendocrine tumors as …
tumors including neuroblastoma. MYCN amplification classifies neuroendocrine tumors as …
Prognostic Evaluation and Functional Characterization of Cyclin K Expression in Endometrial Cancer: Immunohistochemical and In Silico Analysis
Background/Objectives: Endometrial cancer (EC) is a heterogeneous gynecological
malignancy characterized by varied clinical outcomes and complex molecular mechanisms …
malignancy characterized by varied clinical outcomes and complex molecular mechanisms …
[HTML][HTML] Omics-based functional characterization of O-GlcNAcylation and phosphorylation as regulators of transcription
A Gondane - 2024 - helda.helsinki.fi
The flow of information is unidirectional in the cell, where the genetic information stored in
the DNA is transcribed into RNA, which is then translated into proteins. Post-translational …
the DNA is transcribed into RNA, which is then translated into proteins. Post-translational …