Natural polymers have attracted significant attention in drug delivery applications due to
their biocompatibility, biodegradability, and versatility. However, their surface properties …

Introduction Gene delivery technologies are being developed for an increasing number of
biomedical applications, with delivery vehicles including viruses and non-viral materials …

The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …

The blood disorder, β-thalassaemia, is considered an attractive target for gene correction.
Site-specific triplex formation has been shown to induce DNA repair and thereby catalyse …

Cystic fibrosis (CF) is a lethal genetic disorder most commonly caused by the F508del
mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is not …

Mucosal administration of drugs and drug delivery systems has gained increasing interest.
However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require …

Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of
chemical and biological assays. More recently, peptide nucleic acids have also been …

The use of nanoparticles (NPs) as a therapeutic delivery system has expanded markedly
over the past decade, particularly regarding applications targeting the skin. The delivery of …

The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a
polyamide backbone—is continuously increasing in both in vitro and cellular systems and …

Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming
a triplex structure capable of inducing DNA repair and producing specific genome …