Clustered regularly interspaced short palindromic repeats (CRISPR) form the adaptive
immune system in archaea and bacteria and have been modified for genome engineering in …

Staphylococcus aureus is a major opportunistic human pathogen that frequently causes
disease in community and hospital settings. Nasal colonization is an important risk factor for …

The CRISPR–Cas9 system is a powerful tool for genome editing, which allows the precise
modification of specific DNA sequences. Many efforts are underway to use the CRISPR …

Abstract Background Psoriasis impacts 1–3% of the world's population and is characterized
by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level …

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a genome-
editing technology, that utilizes archaeal and bacterial Cas9 nucleases to introduce double …

Staphylococcus aureus is both a commensal organism and also an important opportunistic
human pathogen, causing a variety of community and hospital-associated pathologies, such …

Nucleic acid vaccines represent an attractive approach to vaccination, combining the
positive attributes of both viral vectors and live-attenuated vaccines, without the inherent …

Staphylococcus aureus (S. aureus) causes the vast majority of skin and soft tissue infections
(SSTIs) in humans. S. aureus has become increasingly resistant to antibiotics and there is …

Background: The Surgical Infection Society (SIS) Guidelines for the treatment of complicated
skin and soft tissue infections (SSTIs) were published in October 2009 in Surgical Infections …

Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain
elusive. While the importance of cellular immunity has been shown in mice, T cell responses …