The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …

Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …

β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …