AI in the clinical management of GA: a novel therapeutic universe requires novel tools

GS Reiter, J Mai, S Riedl, K Birner, S Frank… - Progress in Retinal and …, 2024 - Elsevier
Regulatory approval of the first two therapeutic substances for the management of
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a major …

Artificial intelligence in retinal imaging: current status and future prospects

KA Heger, SM Waldstein - Expert review of medical devices, 2024 - Taylor & Francis
Introduction The steadily growing and aging world population, in conjunction with
continuously increasing prevalences of vision-threatening retinal diseases, is placing an …

[HTML][HTML] Disease activity and therapeutic response to pegcetacoplan for geographic atrophy identified by deep learning-based analysis of OCT

U Schmidt-Erfurth, J Mai, GS Reiter, S Riedl, WD Vogl… - Ophthalmology, 2024 - Elsevier
Purpose To quantify morphological changes of the photoreceptors (PRs) and retinal pigment
epithelium (RPE) layers under pegcetacoplan therapy in geographic atrophy (GA) using …

[HTML][HTML] Artificial intelligence for geographic atrophy: pearls and pitfalls

ML Enzendorfer, U Schmidt-Erfurth - Current Opinion in …, 2024 - journals.lww.com
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[HTML][HTML] Deep learning approaches for detecting of nascent geographic atrophy in age-related macular degeneration

H Yao, Z Wu, SS Gao, RH Guymer, V Steffen… - Ophthalmology …, 2024 - Elsevier
Purpose Nascent geographic atrophy (nGA) refers to specific features seen on OCT B-
scans, which are strongly associated with the future development of geographic atrophy …

Quantitative comparison of automated OCT and conventional FAF-based geographic atrophy measurements in the phase 3 OAKS/DERBY trials

J Mai, GS Reiter, S Riedl, WD Vogl, A Sadeghipour… - Scientific Reports, 2024 - nature.com
With the approval of the first two substances for the treatment of geographic atrophy (GA)
secondary to age-related macular degeneration (AMD), a standardized monitoring of …

[HTML][HTML] Therapeutic innovations for geographic atrophy: A promising horizon

EC de Oliveira Figueiredo, C Bucolo… - Current opinion in …, 2024 - Elsevier
This mini review spotlights the most promising treatments for geographic atrophy, the
advanced form of age-related macular degeneration, often resulting in severe and …

Learning spatio-temporal model of disease progression with NeuralODEs from longitudinal volumetric data

D Lachinov, A Chakravarty, C Grechenig… - … on Medical Imaging, 2023 - ieeexplore.ieee.org
Robust forecasting of the future anatomical changes inflicted by an ongoing disease is an
extremely challenging task that is out of grasp even for experienced healthcare …

Phase 2 Trial Evaluating Minocycline for Geographic Atrophy in Age-Related Macular Degeneration: A Nonrandomized Controlled Trial

TDL Keenan, C Bailey, M Abraham… - JAMA …, 2024 - jamanetwork.com
Importance Existing therapies to slow geographic atrophy (GA) enlargement in age-related
macular degeneration (AMD) have relatively modest anatomic efficacy, require intravitreal …

Non-Neovascular Age-Related Macular Degeneration Assessment: Focus on Optical Coherence Tomography Biomarkers

DA Iliescu, AC Ghita, LA Ilie, SE Voiculescu… - Diagnostics, 2024 - mdpi.com
The imagistic evaluation of non-neovascular age-related macular degeneration (AMD) is
crucial for diagnosis, monitoring progression, and guiding management of the disease. Dry …