Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers
Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-
inflammatory, analgesic, and antipyretic effects. Indomethacin became the first-choice drug …
inflammatory, analgesic, and antipyretic effects. Indomethacin became the first-choice drug …
Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents
Novel series of celecoxib analogs endowed with benzofuran moiety 3a–e and 9a–d were
synthesized and evaluated for COX-1/COX-2 inhibitory activity in vitro. The most potent and …
synthesized and evaluated for COX-1/COX-2 inhibitory activity in vitro. The most potent and …
Ultra fine super self-nanoemulsifying drug delivery system (SNEDDS) enhanced solubility and dissolution of indomethacin
The aim of the present investigation was to develop and evaluate ultra fine super self-
nanoemulsifying drug delivery system (SNEDDS) of indomethacin (IND) to enhance its …
nanoemulsifying drug delivery system (SNEDDS) of indomethacin (IND) to enhance its …
An Activity‐Based Sensing Approach for the Detection of Cyclooxygenase‐2 in Live Cells
Abstract Cyclooxygenase‐2 (COX‐2) overexpression is prominent in inflammatory diseases,
neurodegenerative disorders, and cancer. Directly monitoring COX‐2 activity within its …
neurodegenerative disorders, and cancer. Directly monitoring COX‐2 activity within its …
The protective role of Ocimum basilicum L.(Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like …
EA Abd El-Ghffar, E Al-Sayed, SM Shehata… - Food & function, 2018 - pubs.rsc.org
The gastroprotective effect of Ocimum basilicum L.(Basil) hexane extract (OBHE) in aspirin-
induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were …
induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were …
Cinnamaldehyde and eugenol protect against LPS‐stimulated oxidative stress and inflammation in Raw 264.7 cells
Macrophages are leukocytes that play a strategic role in immune response and can be
associated with various diseases due to their effects on the inflammation process and …
associated with various diseases due to their effects on the inflammation process and …
Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats
Clinical studies have shown that anxiolytic and antidepressant drug therapy benefits
patients with ulcers. Many antidepressant drugs have been shown experimentally to …
patients with ulcers. Many antidepressant drugs have been shown experimentally to …
Montelukast prevents mice against acetaminophen-induced liver injury
S Pu, Q Liu, Y Li, R Li, T Wu, Z Zhang… - Frontiers in …, 2019 - frontiersin.org
Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug.
Overdose of APAP is the leading cause of hospital admission for acute liver failure …
Overdose of APAP is the leading cause of hospital admission for acute liver failure …
Pharmacological basis of bergapten in gastrointestinal diseases focusing on H+/K+ ATPase and voltage-gated calcium channel inhibition: A toxicological evaluation …
Aim and objectives: This study aimed to establish a pharmacological basis for evaluating the
effects of bergapten (5-methoxypsoralen) in gastrointestinal diseases and assessment of its …
effects of bergapten (5-methoxypsoralen) in gastrointestinal diseases and assessment of its …
Montelukast attenuates lipopolysaccharide-induced cardiac injury in rats
AE Khodir, HA Ghoneim, MA Rahim… - Human & …, 2016 - journals.sagepub.com
This study investigates the possible protective effects of montelukast (MNT) against
lipopolysaccharide (LPS)-induced cardiac injury, in comparison to dexamethasone (DEX), a …
lipopolysaccharide (LPS)-induced cardiac injury, in comparison to dexamethasone (DEX), a …