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Lipids as mediators of cancer progression and metastasis
Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …
controlled by different regulatory mechanisms. In this context, the contribution of cancer …
Tumor metabolism-rewriting nanomedicines for cancer immunotherapy
X Dong, S **a, S Du, MH Zhu, X Lai, SQ Yao… - ACS Central …, 2023 - ACS Publications
Cancer immunotherapy has become an established therapeutic paradigm in oncologic
therapy, but its therapeutic efficacy remains unsatisfactory in the majority of cancer patients …
therapy, but its therapeutic efficacy remains unsatisfactory in the majority of cancer patients …
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
Platinum prodrug nanoparticles with COX‐2 inhibition amplify pyroptosis for enhanced chemotherapy and immune activation of pancreatic cancer
B Yu, Y Wang, T Bing, Y Tang, J Huang… - Advanced …, 2024 - Wiley Online Library
Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to
trigger a robust antitumor immune response. Platinum‐based chemotherapeutic agents can …
trigger a robust antitumor immune response. Platinum‐based chemotherapeutic agents can …
Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn's disease
In vivo apoptosis of human mesenchymal stromal cells (MSCs) plays a critical role in
delivering immunomodulation. Yet, caspase activity not only mediates the dying process but …
delivering immunomodulation. Yet, caspase activity not only mediates the dying process but …
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME)
that, among its many functions, enables the evasion of T cell-mediated immune responses …
that, among its many functions, enables the evasion of T cell-mediated immune responses …
Comprehensive characterization of HER2-low breast cancers: implications in prognosis and treatment
Y Li, JY Tsang, F Tam, T Loong, MT Gary - EBioMedicine, 2023 - thelancet.com
Background HER2-low cancers are heterogeneous with different degrees of HER2
expression and hormone receptor (HR) status. Currently, its analysis is mostly focused on …
expression and hormone receptor (HR) status. Currently, its analysis is mostly focused on …
Breaking barriers: modulation of Tumor Microenvironment to enhance Bacillus Calmette–Guérin immunotherapy of bladder Cancer
OM Ibrahim, P Kalinski - Cells, 2024 - mdpi.com
The clinical management of bladder cancer continues to present significant challenges.
Bacillus Calmette–Guérin (BCG) immunotherapy remains the gold standard of treatment for …
Bacillus Calmette–Guérin (BCG) immunotherapy remains the gold standard of treatment for …
Tumor cell–intrinsic p38 MAPK signaling promotes IL1α-mediated stromal inflammation and therapeutic resistance in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a KRAS-driven inflammatory
program and a desmoplastic stroma, which contribute to the profoundly chemoresistant …
program and a desmoplastic stroma, which contribute to the profoundly chemoresistant …
[HTML][HTML] Deciphering the roles of aryl hydrocarbon receptor (AHR) in regulating carcinogenesis
Aryl hydrocarbon receptor (AHR) is a ligand-dependent receptor that belongs to the
superfamily of basic helix-loop-helix (bHLH) transcription factors. The activation of the …
superfamily of basic helix-loop-helix (bHLH) transcription factors. The activation of the …