Transforming growth factor β (TGF-β) is a key cytokine regulating the development,
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …

Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Growing interest in exploring mechanically mediated biological phenomena has resulted in
cell culture substrates and 3D matrices with variable stiffnesses becoming standard tools in …

Background Evidence suggests an important role for gut-microbiota dysbiosis in the
development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

Tissue healing and regeneration is a complex, choreographed, spatiotemporal process
involving a plethora of cell types, the activity of which is stringently regulated in order for …

Organoids recapitulate many aspects of the complex three-dimensional (3D) organization
found within native tissues and even display tissue and organ-level functionality. Traditional …

Organoids are a new class of biological model systems that have garnered significant
interest in the life sciences. When provided with the proper 3D matrix and biochemical …

The immune system plays a major role in maintaining many physiological processes in the
reproductive system. However, a complete characterization of the immune milieu in the …

Inflammatory bowel disease causes a major burden to patients and healthcare systems,
raising the need to develop effective therapies. Technological advances in cell culture, allied …