Over the past decade the number and variety of protein post-translational modifications that
have been detected and characterized in bacteria have rapidly increased. Most post …

Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …

Significant developments in the understanding and manipulation of microbial metabolism
have enabled the use of engineered biological systems toward a more sustainable energy …

Background and Aims Most tumor cells use aerobic glycolysis (the Warburg effect) to
support anabolic growth and promote tumorigenicity and drug resistance. Intriguingly, the …

Post-translational modifications (PTMs) are chemical modifications that can regulate the
activity and function of proteins. From an evolutionary perspective, they also represent a fast …

Biomolecules undergo liquid-liquid phase separation (LLPS), resulting in the formation of
multicomponent protein-RNA membraneless organelles in cells. However, the physiological …

Over the past decades, our understanding of microbial metabolism has increased
dramatically. Metabolomics, a family of techniques that are used to measure the quantities of …

Saccharomyces boulardii is a probiotic yeast that exhibits rapid growth at 37° C, is easy to
transform, and can produce therapeutic proteins in the gut. To establish its ability to produce …

Protein serine/threonine/tyrosine (S/T/Y) phosphorylation is an essential and frequent post-
translational modification in eukaryotes, but historically has been considered less prevalent …

The interior of the cell abounds with reactive species that can accumulate as non-enzymatic
covalent modifications (NECMs) on biological macromolecules. These adducts interfere with …