Polypharmacy stewardship: a novel approach to tackle a major public health crisis

R Daunt, D Curtin, D O'Mahony - The Lancet Healthy Longevity, 2023 - thelancet.com
With growing global concern regarding medication-related harm, WHO launched a global
patient safety challenge, Medication Without Harm, in March, 2017. Multimorbidity …

A systematic review of randomised-controlled trials on deprescribing outcomes in older adults with polypharmacy

H Omuya, C Nickel, P Wilson… - International Journal of …, 2023 - academic.oup.com
Background Mixed findings about deprescribing impact have emerged from varied study
designs, interventions, outcome measures and targeting sub-categories of medications or …

Deprescribing medications among older adults from end of hospitalization through postacute care: a Shed-MEDS randomized clinical trial

EE Vasilevskis, AS Shah, EK Hollingsworth… - JAMA Internal …, 2023 - jamanetwork.com
Importance Deprescribing is a promising approach to addressing the burden of
polypharmacy. Few studies have initiated comprehensive deprescribing in the hospital …

[HTML][HTML] STOPP/START criteria for potentially inappropriate prescribing in older people: version 3

D O'Mahony, A Cherubini, AR Guiteras… - European geriatric …, 2023 - Springer
Purpose STOPP/START is a physiological systems-based explicit set of criteria that attempts
to define the clinically important prescribing problems relating to potentially inappropriate …

[HTML][HTML] Polypharmacy

D Varghese, C Ishida, P Patel, HH Koya - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
Objectives: Identify the definition of polypharmacy. Determine the reasons for recognizing
and addressing polypharmacy in the older patients. Develop strategies that can help …

Optimising prescribing in older adults with multimorbidity and polypharmacy in primary care (OPTICA): cluster randomised clinical trial

KT Jungo, AK Ansorg, C Floriani, Z Rozsnyai… - bmj, 2023 - bmj.com
Objective To study the effects of a primary care medication review intervention centred
around an electronic clinical decision support system (eCDSS) on appropriateness of …

Polypharmacy and deprescribing in older adults

W Thompson, EG McDonald - Annual Review of Medicine, 2024 - annualreviews.org
Older adults commonly end up on many medications. Deprescribing is an important part of
individualizing care for older adults. It is an opportunity to discuss treatment options and …

Clinical impact of medication review and deprescribing in older inpatients: a systematic review and meta‐analysis

M Carollo, S Crisafulli, G Vitturi, M Besco… - Journal of the …, 2024 - Wiley Online Library
Background Polypharmacy is a primary risk factor for the prescription of potentially
inappropriate medications (PIMs), drug–drug interactions (DDIs), and ultimately, adverse …

Deprescribing interventions for older patients: a systematic review and meta-analysis

D Zhou, Z Chen, F Tian - Journal of the American Medical Directors …, 2023 - Elsevier
Objectives Deprescribing reduces polypharmacy in older adults. A thorough study of the
effect of deprescribing interventions on clinical outcomes in older adults is presently lacking …

Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper

E van Poelgeest, L Seppala, G Bahat, B Ilhan… - European Geriatric …, 2023 - Springer
Inappropriate polypharmacy is highly prevalent among older adults and presents a
significant healthcare concern. Conducting medication reviews and implementing …