[HTML][HTML] Tellurium and gold enrichment aided by melts and pyrite crystallization kinetics: Insights from the Yongxin gold deposit, northeast China
The Yongxin gold deposit, in the southern part of the Duobaoshan polymetallic metallogenic
belt (DPMB), northeast China, is an epithermal gold deposit with 21 tons of identified gold …
belt (DPMB), northeast China, is an epithermal gold deposit with 21 tons of identified gold …
Perspectives on the current state, challenges, and opportunities in pharmaceutical crystallization process development
Crystallization is the primary process used to purify synthetic drug substances and
intermediates as well as to control bulk properties, including particle size, surface area, and …
intermediates as well as to control bulk properties, including particle size, surface area, and …
Impurity incorporation in solution crystallization: diagnosis, prevention, and control
Despite their widespread use for purification, our current methods for the development of
solution crystallization processes lack a sufficient understanding on how impurities …
solution crystallization processes lack a sufficient understanding on how impurities …
Prevalence of impurity retention mechanisms in pharmaceutical crystallizations
The rejection of process impurities from crystallizing products is an essential step for the
purification of pharmaceutical drugs and for the isolation of active pharmaceutical …
purification of pharmaceutical drugs and for the isolation of active pharmaceutical …
Mathematical modeling and optimization to inform impurity control in an industrial active pharmaceutical ingredient manufacturing process
Mathematical modeling of pharmaceutical manufacturing processes can provide insights
and understanding regarding the key factors impacting product quality. In this study, we …
and understanding regarding the key factors impacting product quality. In this study, we …
Model-based optimization of cooling crystallization of active pharmaceutical ingredients undergoing thermal degradation
Many active pharmaceutical ingredients (APIs) undergo degradation at high temperature.
Optimum cooling profiles from first principle models usually do not consider this degradation …
Optimum cooling profiles from first principle models usually do not consider this degradation …
Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization–Part 2: Industrial Case Studies
Three industrial case studies are presented from the pharmaceutical companies Boehringer-
Ingelheim and Merck & Co., Inc.(Rahway, NJ) demonstrating how solid-state miscible …
Ingelheim and Merck & Co., Inc.(Rahway, NJ) demonstrating how solid-state miscible …
Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity …
Crystallization is routinely employed in industrial chemical synthesis to remove undesired
impurities and obtain the product as a crystalline solid. A common impurity retention …
impurities and obtain the product as a crystalline solid. A common impurity retention …
Case studies in the application of a workflow-based crystallization design for optimized impurity rejection in pharmaceutical development
Crystallization is an important unit operation in pharmaceutical drug substance
manufacturing for the isolation of organic products. Impurity control is a recurring critical …
manufacturing for the isolation of organic products. Impurity control is a recurring critical …
Material impurity distribution of lattice-incorporated impurities in salicylic acid
The mechanisms of purging structurally similar impurities in solution crystallization have
been evaluated using the model compound salicylic acid. Of the 11 added impurities, 3 …
been evaluated using the model compound salicylic acid. Of the 11 added impurities, 3 …