[HTML][HTML] The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?

A Marx, JKC Chan, L Chalabreysse, S Dacic… - Journal of Thoracic …, 2022‏ - Elsevier
This overview of the fifth edition of the WHO classification of thymic epithelial tumors
(including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]) …

The contemporary management of cancers of the sinonasal tract in adults

R Thawani, MS Kim, A Arastu, Z Feng… - CA: a cancer journal …, 2023‏ - Wiley Online Library
Sinonasal malignancies make up< 5% of all head and neck neoplasms, with an incidence of
0.5–1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas …

[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …

G Rindi, DS Klimstra, B Abedi-Ardekani, SL Asa… - Modern Pathology, 2018‏ - Elsevier
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

BET proteins as targets for anticancer treatment

A Stathis, F Bertoni - Cancer discovery, 2018‏ - aacrjournals.org
Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate
gene expression and are involved in cancer pathogenesis. Over the last years, several BET …

[HTML][HTML] Best practices recommendations for diagnostic immunohistochemistry in lung cancer

Y Yatabe, S Dacic, AC Borczuk, A Warth… - Journal of thoracic …, 2019‏ - Elsevier
Since the 2015 WHO classification was introduced into clinical practice,
immunohistochemistry (IHC) has figured prominently in lung cancer diagnosis. In addition to …

[HTML][HTML] The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification

WD Travis, E Brambilla, AG Nicholson, Y Yatabe… - Journal of thoracic …, 2015‏ - Elsevier
Abstract The 2015 World Health Organization (WHO) Classification of Tumors of the Lung,
Pleura, Thymus and Heart has just been published with numerous important changes from …

Clinical response of carcinomas harboring the BRD4–NUT oncoprotein to the targeted bromodomain inhibitor OTX015/MK-8628

A Stathis, E Zucca, M Bekradda, C Gomez-Roca… - Cancer …, 2016‏ - aacrjournals.org
The antineoplastic, prodifferentiative effects of bromodomain and extra-terminal (BET)
bromodomain (BRD) inhibitors were initially discovered in NUT midline carcinoma (NMC) …

Selective inhibition of BET bromodomains

P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith… - Nature, 2010‏ - nature.com
Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts
have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and …

Update from the 5th Edition of the World Health Organization classification of head and neck tumors: nasal cavity, paranasal sinuses and skull base

LDR Thompson, JA Bishop - Head and neck pathology, 2022‏ - Springer
Abstract The World Health Organization Classification of Head and Neck Tumours recently
published the 5th edition. There are new entities, emerging entities, and significant updates …

An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients

NG Chau, C Ma, K Danga, H Al-Sayegh… - JNCI Cancer …, 2020‏ - academic.oup.com
Background NUT midline carcinoma, renamed NUT carcinoma (NC), is an aggressive
squamous cancer defined by rearrangement of the NUTM1 gene. Although a subset of …