Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
Chalcone: a promising bioactive scaffold in medicinal chemistry
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer
Novel halogenated phenoxychalcones 2a–f and their corresponding N-acetylpyrazolines 3a–
f were synthesised and evaluated for their anticancer activities against breast cancer cell …
f were synthesised and evaluated for their anticancer activities against breast cancer cell …
Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells
MB Dos Santos, D Bertholin Anselmo… - Journal of enzyme …, 2019 - Taylor & Francis
Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum.
In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast …
In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast …
In silico screening of chalcone derivatives as promising EGFR-TK inhibitors for the clinical treatment of cancer
Epidermal growth factor receptor (EGFR) promotes tumorigenic characteristics and activates
cancer-associated signaling pathways such as Wnt/-catenin, transforming growth factor …
cancer-associated signaling pathways such as Wnt/-catenin, transforming growth factor …
Biological evaluation and molecular dynamics simulation of chalcone derivatives as epidermal growth factor-tyrosine kinase inhibitors
K Sangpheak, L Tabtimmai, S Seetaha, C Rungnim… - Molecules, 2019 - mdpi.com
Targeted cancer therapy has become a high potential cancer treatment. Epidermal growth
factor receptor (EGFR), which plays an important role in cell signaling, enhanced cell …
factor receptor (EGFR), which plays an important role in cell signaling, enhanced cell …
Discovery of anti-hypertensive oligopeptides from adlay based on in silico proteolysis and virtual screening
L Qiao, B Li, Y Chen, L Li, X Chen, L Wang… - International journal of …, 2016 - mdpi.com
Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM)
with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay …
with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay …
Molecular structure and mesomorphism: Effect of tail/lateral group
VS Sharma, RB Patel - Molecular Crystals and Liquid Crystals, 2016 - Taylor & Francis
Chalconyl homologous series of novel mesogenic substances of molecular structure RO-
C6H4-COO-C6H4-CO-CH: CH-C6H4-OC16H33 (P) has been studied with a view to …
C6H4-COO-C6H4-CO-CH: CH-C6H4-OC16H33 (P) has been studied with a view to …
Molecular flexibility dependence mesomorphism
VS Sharma, RB Patel - Molecular Crystals and Liquid Crystals, 2016 - Taylor & Francis
ABSTRACT A novel series of chalconyl homologue derivatives with RO. C6H4. COO. C6H4.
CO. CH: CH-C6H4. N.(CH3) 2 (Para) have been synthesized and thermotropically studied …
CO. CH: CH-C6H4. N.(CH3) 2 (Para) have been synthesized and thermotropically studied …
Mesomorphism dependence on molecular rigidity and substitution of same functional group on lateral or terminal position of tailed phenyl ring
VS Sharma, RB Patel - Molecular Crystals and Liquid Crystals, 2017 - Taylor & Francis
Novel liquid crystal materials (LCs) of low temperature range (53° C to 75° C) have been
synthesized through a series of chalconyl derivatives consisting of two phenyl rings bonded …
synthesized through a series of chalconyl derivatives consisting of two phenyl rings bonded …