Soft robotics technologies are paving the way toward robotic abilities which are vital for a
wide range of applications, including manufacturing, manipulation, grip**, human …

The correct identification of differentially expressed genes (DEGs) between specific
conditions is a key in the understanding phenotypic variation. High-throughput transcriptome …

Most genetic variants identified from genome-wide association studies (GWAS) in humans
are noncoding, indicating their role in gene regulation. Previous studies have shown …

Decades of work have elucidated cytokine signalling and transcriptional pathways that
control T cell differentiation and have led the way to targeted biologic therapies that are …

Most approaches to transcript quantification rely on fixed reference annotations; however,
the transcriptome is dynamic and depending on the context, such static annotations contain …

Large-scale sequencing of RNA from individual cells can reveal patterns of gene, isoform
and allelic expression across cell types and states. However, current short-read single-cell …

Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but
there remain challenges towards achieving this goal,,,,–. Here we generate human islet-like …

The rapid development of high-throughput sequencing techniques has led biology into the
big-data era. Data analyses using various bioinformatics tools rely on programming and …

INTRODUCTION Laboratory mice are a mainstay of biomedical research and have been
instrumental for many important discoveries in the field of immunology. However, there are …

Abstract N 6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory
mechanism affecting cell differentiation and proliferation in development and cancer. To …