Amide bond bioisosteres: Strategies, synthesis, and successes
The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …
many clinically approved drugs. Bioisosterism is widely employed in the rational …
Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review
The leading cause of several degenerative diseases such as atherosclerosis, cancer, aging,
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
Antimicrobial activity of 1, 3, 4-oxadiazole derivatives
The worldwide development of antimicrobial resistance forces scientists to search for new
compounds to which microbes would be sensitive. Many new structures contain the 1, 3, 4 …
compounds to which microbes would be sensitive. Many new structures contain the 1, 3, 4 …
Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic …
In contemporary medicinal chemistry, employing a singular small molecule to concurrently
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …
1, 2, 4-and 1, 3, 4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents
P Pitasse-Santos, V Sueth-Santiago… - Journal of the Brazilian …, 2018 - SciELO Brasil
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design
and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the …
and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the …
Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation
2-Amino-substituted 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles were synthesized via
condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes …
condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes …
An understanding of mechanism-based approaches for 1, 3, 4-oxadiazole scaffolds as cytotoxic agents and enzyme inhibitors
The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …
new drugs to treat cancer. There has been a significant improvement in understanding the …
A review exploring therapeutic worth of 1, 3, 4-oxadiazole tailored compounds
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
I2-Mediated Oxidative C–O Bond Formation for the Synthesis of 1,3,4-Oxadiazoles from Aldehydes and Hydrazides
A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1, 3, 4-
oxadiazoles has been developed by employing stoichiometric molecular iodine in the …
oxadiazoles has been developed by employing stoichiometric molecular iodine in the …
General α‐amino 1, 3, 4‐oxadiazole synthesis via late‐stage reductive functionalization of tertiary amides and lactams
D Matheau‐Raven, DJ Dixon - … Chemie International Edition, 2021 - Wiley Online Library
An iridium‐catalyzed reductive three‐component coupling reaction for the synthesis of
medicinally relevant α‐amino 1, 3, 4‐oxadiazoles from abundant tertiary amides or lactams …
medicinally relevant α‐amino 1, 3, 4‐oxadiazoles from abundant tertiary amides or lactams …