Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

Genetic association studies, in particular the genome-wide association study (GWAS)
design, have provided a wealth of novel insights into the aetiology of a wide range of human …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Integration of genome-wide association studies (GWAS) and expression quantitative trait
loci (eQTL) studies is needed to improve our understanding of the biological mechanisms …

The genetic association of the major histocompatibility complex (MHC) to rheumatoid
arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate …

Although genome-wide association studies (GWASs) have identified numerous loci
associated with complex traits, imprecise modeling of the genetic relatedness within study …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Shared aetiopathogenic factors among immune-mediated diseases have long been
suggested by their co-familiality and co-occurrence, and molecular support has been …