Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Urine-derived stem cells (USCs) have gained the attention of researchers in the biomedical
field in the past few years. Regarding the several varieties of cells that have been used for …

Pluripotency reprogramming and transdifferentiation induced by transcription factors can
generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the …

Abstract Human induced Pluripotent Stem Cells (iPSCs) have enormous potential in
understanding developmental biology, disease modeling, drug discovery, and regenerative …

More than a decade ago, a pioneering study reported generation of induced Pluripotent
Stem Cells (iPSCs) by ectopic expression of a cocktail of reprogramming factors in …

Transplantation of insulin-secreting cells provides a promising method for re-establishing
the autonomous blood glucose control ability of type 1 diabetes (T1D) patients, but the low …

Bone disorders are a group of varied acute and chronic traumatic, degenerative, malignant
or congenital conditions affecting the musculoskeletal system. They are prevalent in society …

The ground state of embryonic stem cells (ESCs) is closely related to the development of
regenerative medicine. Particularly, long-term culture of ESCs in vitro, maintenance of their …

Human pluripotent stem cells (hPSCs) exhibit very limited contribution to interspecies
chimeras. One explanation is that the conventional hPSCs are in a primed state and so …

Background Human induced pluripotent stem cells (iPSCs) are a promising tool to
investigate pathogenic mechanisms underlying human genetic conditions, such as …