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ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
The DNA damage-induced cell death response: a roadmap to kill cancer cells
Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …
death response. Resistance to cell death is linked to cellular transformation and …
ATM and related protein kinases: safeguarding genome integrity
Maintenance of genome stability is essential for avoiding the passage to neoplasia. The
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic …
Through sequencing analysis of blood or bone marrow samples from patients with chronic
myeloid leukemia, we identified BCR-ABL kinase domain mutations in 29 of 32 patients …
myeloid leukemia, we identified BCR-ABL kinase domain mutations in 29 of 32 patients …
p53 and human cancer: the first ten thousand mutations
Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …
The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)
Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …
ecstasy) is a popular recreational drug among young people, particularly those involved in …
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
First described over 80 years ago, ataxia-telangiectasia (AT) was defined as a clinical entity
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …
Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers
Oncogene-induced DNA damage elicits genomic instability in epithelial cancer cells, but
apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological …
apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological …
DNA damage-induced apoptosis
Unicellular organisms respond to the presence of DNA lesions by activating cell cycle
checkpoint and repair mechanisms, while multicellular animals have acquired the further …
checkpoint and repair mechanisms, while multicellular animals have acquired the further …
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
The Brca1 (breast cancer gene 1) tumor suppressor protein is phosphorylated in response
to DNA damage. Results from this study indicate that the checkpoint protein kinase ATM …
to DNA damage. Results from this study indicate that the checkpoint protein kinase ATM …