Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's
disease and are at very high risk of develo** early-onset dementia, which is now the …

The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …

Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …