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Alzheimer's disease associated with Down syndrome: a genetic form of dementia
Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's
disease and are at very high risk of develo** early-onset dementia, which is now the …
disease and are at very high risk of develo** early-onset dementia, which is now the …
[HTML][HTML] Vascular cognitive impairment (VCI)
Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …
[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
[HTML][HTML] White matter aging drives microglial diversity
Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …
The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
A global view of the genetic basis of Alzheimer disease
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
Cognitive impact of COVID-19: looking beyond the short term
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
Vascular dysfunction—the disregarded partner of Alzheimer's disease
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …
[HTML][HTML] Emerging concepts in vascular dementia: a review
Abstract Objective Vascular dementia (VaD) is the second most common cause of dementia
and a major health concern worldwide. A comprehensive review on VaD is warranted for …
and a major health concern worldwide. A comprehensive review on VaD is warranted for …