Unveiling the Therapeutic Potential of Quinazolinone Derivatives in Cancer Treatment: A Comprehensive Exploration
J Kaur, S Kaur, Muskan, N Kaur, V Kumar… - …, 2024 - Wiley Online Library
Quinazolinone derivatives have garnered attention for their diverse biological activities,
including anticancer properties. This review combines findings from 2018 to 2024, focusing …
including anticancer properties. This review combines findings from 2018 to 2024, focusing …
Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3‐d]pyrimidine derivatives as EGFR inhibitors
Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …
National Cancer Institute evaluated all the newly synthesized compounds for their …
Novel quinazolinone derivatives as anticancer agents: Design, synthesis, biological evaluation and computational studies
A novel series of quinazoline-pyrimidine derivatives (3a-3i) linked to different aryl
substitutions were designed and synthesized as promising anti-cancer candidates. The …
substitutions were designed and synthesized as promising anti-cancer candidates. The …
Arene Ruthenium(II)-Catalyzed Sustainable Synthesis of 2,4-Disubstituted Quinazolines via Acceptorless Dual Dehydrogenative Coupling of Alcohols
S Sundar, T Veerappan… - The Journal of …, 2023 - ACS Publications
We demonstrate an efficient and sustainable strategy for the direct synthesis of 2, 4-
disubstituted quinazolines by arene Ru (II) benzhydrazone complex via the eco-friendly …
disubstituted quinazolines by arene Ru (II) benzhydrazone complex via the eco-friendly …
Azole-methyl-3-(4-phenoxyphenyl) quinazolin-4 (3H) ones, novel quinazoline-azole hybrid scaffolds, as new potent anticancer agents: Design, synthesis, biological …
Herein we describe design and synthesis of new series of small quinazoline molecule
connected to the azole moieties. Molecular docking screening were conducted on 102 …
connected to the azole moieties. Molecular docking screening were conducted on 102 …
6-Bromo quinazoline derivatives as cytotoxic agents: Design, synthesis, molecular docking and MD simulation
L Emami, M Hassani, P Mardaneh, F Zare, M Saeedi… - BMC chemistry, 2024 - Springer
Based on unselectively, several side effects and drug resistance of available anticancer
agents, the development and research for novel anticancer agents is necessary. In this …
agents, the development and research for novel anticancer agents is necessary. In this …
[HTML][HTML] Methodical selected coptisine attenuates the malignancy of cholangiocarcinoma through the blockade of EGFR signalling
The aim of the present study is to provide a methodical platform for the development of lead
compounds against cholangiocarcinoma. Coptisine was selected as a potential anti-cancer …
compounds against cholangiocarcinoma. Coptisine was selected as a potential anti-cancer …
Microwave accelerated green access to functionalized pyrazolo [5, 1-b] quinazoline-3-carboxylate scaffold and their pharmacological screening
Herein, we explored an environmentally benign synthesis of pyrazolo [5, 1-b] quinazoline-3-
carboxylate derivatives 4 (au) as potential antimicrobial, antitubercular as well as …
carboxylate derivatives 4 (au) as potential antimicrobial, antitubercular as well as …
Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)-quinazolinone derivatives
Cancer is a broad classification of diseases that can affect any organ or body tissue due to
aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs …
aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs …
Novel uracil derivatives as anti-cancer agents: Design, synthesis, biological evaluation and computational studies
L Baziyar, P Ahmadi, SZ Gheshlaghi, M Behrouz… - Journal of Molecular …, 2024 - Elsevier
Ten novel uracil-azole hybrides (4a-4j) were designed and synthesized as anti-cancer
agents. IR, 1 HNMR, 13 CNMR, and Mass spectroscopy were applied to confirm the …
agents. IR, 1 HNMR, 13 CNMR, and Mass spectroscopy were applied to confirm the …