Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one
of the most serious chronic heart diseases and has become a major cause of heart failure …

In the genesis and progression of cardiovascular diseases involving both innate and
adaptive immune responses, inflammation plays a pivotal and dual role. Studies in …

Aims Aging entails profound immunological transformations that can impact myocardial
homeostasis and predispose to heart failure. However, preclinical research in the immune …

Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial
infection. However, these processes may also be activated during the pathogenesis of non …

Small molecules (less than 1,500 Da) include major biological signals that mediate host-
pathogen-microbiome communication. They also include key intermediates of metabolism …

Immunometabolism is an emerging field at the intersection of immunology and metabolism.
Immune cell activation plays a critical role in the pathogenesis of cardiovascular diseases …

Ferroptosis is an emerging form of non-apoptotic, regulated cell death that is mechanistically
dependent on aberrant iron accumulation and excessive lipid peroxidation. Further …

Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi, is a neglected
disease affecting around 6 million people. About 30% of CD patients develop chronic …

This study aimed to investigate the potential of nebivolol in preventing doxorubicin-induced
cardiotoxicity by targeting the inflammatory, oxidative, and apoptotic pathways. Twenty-eight …