Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

Ischemia‐reperfusion injury (IRI) has indeed been shown as a main complication of
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …

Patients having experienced the ischemia-reperfusion process are particularly vulnerable to
subsequent heart attacks because this process can induce myocardial fibrosis, hallmarked …

Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …

Liver diseases represent a major global health burden accounting for approximately 2
million deaths per year worldwide. The liver functions as a primary immune organ that is …

The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3
(NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1 …

Background: Despite continuous progress in the field of liver transplantation, considerable
proportion of patients still suffer from the postoperative graft dysfunction. Clinically, it …

Liver transplantation is the most effective treatment for end-stage liver disease. Transplant
indications have been progressively increasing, with a huge discrepancy between the …

Long-time ischemia worsening transplant outcomes in vascularized composite
allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an …

The innate system constitutes a first-line defence mechanism against pathogens. 80% of the
blood supply entering the human liver arrives from the splanchnic circulation through the …