Toll-like receptor signalling in B cells during systemic lupus erythematosus
B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …
Competence and competition: the challenge of becoming a long-lived plasma cell
A Radbruch, G Muehlinghaus, EO Luger… - Nature Reviews …, 2006 - nature.com
Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-
lived end-stage products of B-cell differentiation that deserve little interest. This view is …
lived end-stage products of B-cell differentiation that deserve little interest. This view is …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
A phase III, randomized, placebo‐controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus …
R Furie, M Petri, O Zamani, R Cervera… - Arthritis & …, 2011 - Wiley Online Library
Objective To assess the efficacy/safety of the B lymphocyte stimulator inhibitor belimumab
plus standard therapy compared with placebo plus standard therapy in active systemic lupus …
plus standard therapy compared with placebo plus standard therapy in active systemic lupus …
UNC93B1 variants underlie TLR7-dependent autoimmunity
UNC93B1 is critical for trafficking and function of nucleic acid–sensing Toll-like receptors
(TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive …
(TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive …
Antibody-independent functions of B cells: a focus on cytokines
P Shen, S Fillatreau - Nature Reviews Immunology, 2015 - nature.com
Cytokine production by B cells is important for multiple aspects of immunity. B cell-derived
cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and …
cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and …
The risk of lymphoma development in autoimmune diseases: a meta-analysis
Background The risk of development of non-Hodgkin lymphoma (NHL) in autoimmune
patients has been investigated in several cohort studies. These studies revealed …
patients has been investigated in several cohort studies. These studies revealed …
Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
C Mohan, C Putterman - Nature Reviews Nephrology, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
Effector and regulatory B cells: modulators of CD4+ T cell immunity
FE Lund, TD Randall - Nature Reviews Immunology, 2010 - nature.com
B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …
cell responses remains controversial. However, new data showing that the transient …
[HTML][HTML] PD-1hiCXCR5–T peripheral helper cells promote B cell responses in lupus via MAF and IL-21
AV Bocharnikov, J Keegan, VS Wacleche, Y Cao… - JCI insight, 2019 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …