Toll-like receptor signalling in B cells during systemic lupus erythematosus
B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …
Antibody-independent functions of B cells: a focus on cytokines
P Shen, S Fillatreau - Nature Reviews Immunology, 2015 - nature.com
Cytokine production by B cells is important for multiple aspects of immunity. B cell-derived
cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and …
cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and …
UNC93B1 variants underlie TLR7-dependent autoimmunity
UNC93B1 is critical for trafficking and function of nucleic acid–sensing Toll-like receptors
(TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive …
(TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
[HTML][HTML] PD-1hiCXCR5–T peripheral helper cells promote B cell responses in lupus via MAF and IL-21
AV Bocharnikov, J Keegan, VS Wacleche, Y Cao… - JCI insight, 2019 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …
A phase III, randomized, placebo‐controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus …
R Furie, M Petri, O Zamani, R Cervera… - Arthritis & …, 2011 - Wiley Online Library
Objective To assess the efficacy/safety of the B lymphocyte stimulator inhibitor belimumab
plus standard therapy compared with placebo plus standard therapy in active systemic lupus …
plus standard therapy compared with placebo plus standard therapy in active systemic lupus …
Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
C Mohan, C Putterman - Nature Reviews Nephrology, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
Pathophysiology of T follicular helper cells in humans and mice
Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …
induce the differentiation of B cells into plasma cells and memory cells. They are found …
Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations
Objectives We examined the utility of circulating total and IgG4+ plasmablasts as biomarkers
of diagnosis and disease activity in IgG4-related disease (IgG4-RD). Materials methods We …
of diagnosis and disease activity in IgG4-related disease (IgG4-RD). Materials methods We …
Altered B cell signalling in autoimmunity
DJ Rawlings, G Metzler, M Wray-Dutra… - Nature reviews …, 2017 - nature.com
Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …