There has been considerable recent progress in protein structure prediction using deep
neural networks to predict inter-residue distances from amino acid sequences,–. Here we …

Degeneracy in the genetic code, which enables a single protein to be encoded by a
multitude of synonymous gene sequences, has an important role in regulating protein …

Unlike random heteropolymers, natural proteins fold into unique ordered structures.
Understanding how these are encoded in amino-acid sequences is complicated by …

Analytical size-exclusion chromatography (SEC), commonly used for the determination of
the molecular weight of proteins and protein-protein complexes in solution, is a relative …

We have developed an approach for determining NMR structures of proteins over 20 kDa
that utilizes sparse distance restraints obtained using transverse relaxation optimized …

Active sites and ligand-binding cavities in native proteins are often formed by curved β
sheets, and the ability to control β-sheet curvature would allow design of binding proteins …

Antibodies are key reagents in biology and medicine, but commercial sources are rarely
recombinant and thus do not provide a permanent and renewable resource. Here, we …

Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases.
However, it remains a grand challenge to extract molecular structure information from …

Antimicrobial peptides (AMPs) have attracted attention as alternatives to classic antibiotics
due to their expected limited pressure on bacterial resistance mechanisms. Yet, their modes …

Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and
inflammation. In addition, prophylactic use of acetylsalicylic acid, commonly known as …