The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
MA Atkinson, RG Mirmira - Cell Metabolism, 2023 - cell.com
Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
The human islet: mini-organ with mega-impact
This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …
development, function, and dysfunction. After providing a historical timeline of key …
[HTML][HTML] SARS-CoV-2 cell entry factors ACE2 and TMPRSS2 are expressed in the microvasculature and ducts of human pancreas but are not enriched in β cells
Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the
hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would …
hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would …
Genetic evidence for different adiposity phenotypes and their opposing influences on ectopic fat and risk of cardiometabolic disease
To understand the causal role of adiposity and ectopic fat in type 2 diabetes and
cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants …
cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants …
Unravelling checkpoint inhibitor associated autoimmune diabetes: from bench to bedside
Immune checkpoint inhibitors have transformed the landscape of oncological therapy, but at
the price of a new array of immune related adverse events. Among these is β-cell failure …
the price of a new array of immune related adverse events. Among these is β-cell failure …
Exocrine-endocrine crosstalk: The influence of pancreatic cellular communications on organ growth, function and disease
DL Overton, TL Mastracci - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …
Localization of enteroviral RNA within the pancreas in donors with T1D and T1D-associated autoantibodies
Enteroviral infections have been associated with autoimmunity and type 1 diabetes (T1D),
but reliable methods to ascertain localization of single infected cells in the pancreas were …
but reliable methods to ascertain localization of single infected cells in the pancreas were …
Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity
JJ Wright, A Eskaros, A Windon, R Bottino… - Diabetes, 2024 - diabetesjournals.org
The endocrine and exocrine compartments of the pancreas are spatially related but
functionally distinct. Multiple diseases affect both compartments, including type 1 diabetes …
functionally distinct. Multiple diseases affect both compartments, including type 1 diabetes …
Exocrine pancreatic enzymes are a serological biomarker for type 1 diabetes staging and pancreas size
Exocrine pancreas abnormalities are increasingly recognized as features of type 1 diabetes.
We previously reported reduced serum trypsinogen levels and in a separate study, smaller …
We previously reported reduced serum trypsinogen levels and in a separate study, smaller …