Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor
initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major …

Abstract Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for
3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC …

In human vascular anatomy, blood flows from the heart to organs and tissues through a
hierarchical vascular tree, comprising large arteries that branch into arterioles and further …

Abstract Organ-on-chip (OoC) platforms are a new class of advanced microfluidic devices
that have been attracting significant attention for drug development since they can allow a …

Lymph nodes (LNs) are organs of the immune system, critical for maintenance of
homeostasis and initiation of immune responses, yet there are few models that accurately …

Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in
vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale …

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …

Microphysiological and organ‐on‐chip platforms seek to address critical gaps in human
disease models and drug development that underlie poor rates of clinical success for novel …

The knowledge of the blood microvasculature and its functional role in health and disease
has grown significantly attributable to decades of research and numerous advances in cell …