DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …

Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …

Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks,
leading to cell lethality. To understand the molecular mechanisms underlying this process …

Standard CRISPR-mediated gene disruption strategies rely on Cas9-induced DNA double-
strand breaks (DSBs). Here, we show that CRISPR-dependent base editing efficiently …

Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor
rejection. However, cancer cells often evade these responses by overexpressing immune …

The remodelling of replication forks into four-way junctions following replication perturbation,
known as fork reversal, was hypothesized to promote DNA damage tolerance and repair …

The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …

DNA replication stress can stall replication forks, leading to genome instability. DNA damage
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …

Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit
genetic information to our offspring as well as our own survival. To respond to these threats …