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FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions
3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
Structural insights into the functional roles of 14-3-3 proteins
V Obsilova, T Obsil - Frontiers in molecular biosciences, 2022 - frontiersin.org
Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …
extracellular environment to intracellular compartments, thereby eliciting an appropriate …
ER stress: Autophagy induction, inhibition and selection
HO Rashid, RK Yadav, HR Kim, HJ Chae - Autophagy, 2015 - Taylor & Francis
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
[HTML][HTML] Redox regulation of FoxO transcription factors
LO Klotz, C Sánchez-Ramos, I Prieto-Arroyo… - Redox biology, 2015 - Elsevier
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …
the cellular stress response and promote the cellular antioxidant defense. On one hand …
FOXOs: signalling integrators for homeostasis maintenance
A Eijkelenboom, BMT Burgering - Nature reviews Molecular cell biology, 2013 - nature.com
Forkhead box O (FOXO) transcription factors are involved in the regulation of the cell cycle,
apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell …
apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell …
High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics
Mass spectrometry has enabled the study of cellular signaling on a systems-wide scale,
through the quantification of post-translational modifications, such as protein …
through the quantification of post-translational modifications, such as protein …
Metabolic regulation of hematopoietic stem cells in the hypoxic niche
Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent
differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone …
differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone …
[HTML][HTML] FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
The forkhead box O (FoxO) transcription factor family is a key player in an evolutionary
conserved pathway downstream of insulin and insulin-like growth factor receptors. The …
conserved pathway downstream of insulin and insulin-like growth factor receptors. The …
Redox regulation of SIRT1 in inflammation and cellular senescence
J Hwang, H Yao, S Caito, IK Sundar… - Free Radical Biology and …, 2013 - Elsevier
Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …