Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Bioorthogonal chemistry

SL Scinto, DA Bilodeau, R Hincapie, W Lee… - Nature Reviews …, 2021 - nature.com
Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Hydrogen-bonded organic framework-based bioorthogonal catalysis prevents drug metabolic inactivation

C Huang, C Zhao, Q Deng, H Zhang, D Yu, J Ren… - Nature Catalysis, 2023 - nature.com
Bioorthogonal chemistry provides a new avenue for disease treatment by generating
therapeutic agents in situ. However, two crucial issues have to be considered for future …

A bioorthogonal system reveals antitumour immune function of pyroptosis

Q Wang, Y Wang, J Ding, C Wang, X Zhou, W Gao… - Nature, 2020 - nature.com
Bioorthogonal chemistry capable of operating in live animals is needed to investigate
biological processes such as cell death and immunity. Recent studies have identified a …

Bioorthogonal-activated in situ vaccine mediated by a COF-based catalytic platform for potent cancer immunotherapy

M Sun, Z Liu, L Wu, J Yang, J Ren… - Journal of the American …, 2023 - ACS Publications
Personalized tumor vaccines have become a promising modality for cancer immunotherapy.
However, in situ personalized tumor vaccines generated from immunogenic cancer cell …

[HTML][HTML] Chitosan-based nanostructured biomaterials: Synthesis, properties, and biomedical applications

M Ul-Islam, KF Alabbosh, S Manan, S Khan… - Advanced industrial and …, 2024 - Elsevier
Chitosan is obtained from chitin, which is abundantly found in crustaceans and obtained
through various methods. The demineralization, deproteinization, discoloration, and …

[HTML][HTML] Recent progress in drug delivery

C Li, J Wang, Y Wang, H Gao, G Wei, Y Huang… - … pharmaceutica sinica B, 2019 - Elsevier
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to
desired tissues, organs, cells and subcellular organs for drug release and absorption …

Metal-organic frameworks for stimuli-responsive drug delivery

Y Wang, J Yan, N Wen, H **ong, S Cai, Q He, Y Hu… - Biomaterials, 2020 - Elsevier
Abstract Metal-organic framework (MOF), a novel hybrid porous material which is
composited by metal ions and organic linkers, has drawn increasing attention and became a …

Metal-free bioorthogonal click chemistry in cancer theranostics

D Wu, K Yang, Z Zhang, Y Feng, L Rao… - Chemical Society …, 2022 - pubs.rsc.org
Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Bioorthogonal disruption of pyroptosis checkpoint for high-efficiency pyroptosis cancer therapy

W Zhang, Z Liu, J Zhu, Z Liu, Y Zhang… - Journal of the …, 2023 - ACS Publications
Pyroptosis is an inflammatory form of programmed cell death that holds great promise in
cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self …