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Computational Tools to Assist in Analyzing Effects of the SERPINA1 Gene Variation on Alpha-1 Antitrypsin (AAT)
In the rapidly advancing field of bioinformatics, the development and application of
computational tools to predict the effects of single nucleotide variants (SNVs) are shedding …
computational tools to predict the effects of single nucleotide variants (SNVs) are shedding …
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
Triangulating variation in the population to define mechanisms for precision management of genetic disease
To understand mechanistically how the protein fold is shaped by therapeutics to inform
precision management of disease, we developed variation-capture (VarC) map**. VarC …
precision management of disease, we developed variation-capture (VarC) map**. VarC …
Understanding the host-pathogen evolutionary balance through Gaussian process modeling of SARS-CoV-2
We have developed a machine learning (ML) approach using Gaussian process (GP)-based
spatial covariance (SCV) to track the impact of spatial-temporal mutational events driving …
spatial covariance (SCV) to track the impact of spatial-temporal mutational events driving …