Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Alternative splicing (AS) can critically affect gene function and disease, yet map** splicing
variations remains a challenge. Here, we propose a new approach to define and quantify …

The “Amyloid Cascade Hypothesis” has dominated the Alzheimer's disease (AD) field in the
last 25 years. It posits that the increase of amyloid-β (Aβ) is the key event in AD that triggers …

Just as neuronal activity is essential to normal brain function, microtubule-associated protein
tau appears to be critical to normal neuronal activity in the mammalian brain, especially in …

Microtubule-associated proteins (MAP), such as tau, modulate the extent and rate of
microtubule assembly and play an essential role in morphogenetic processes, such as …

Preparations of dispersed paired helical filaments (PHFs) from the brains of Alzheimer's
disease and Down's syndrome patients display on gels three principal bands corresponding …

Tau protein, a component of Alzheimer paired helical filaments, can be phosphorylated by
several kinases. Of particular interest is the phosphorylation at Ser/Thr-Pro motifs because …

MARK phosphorylates the microtubule-associated proteins tau, MAP2, and MAP4 on their
microtubule-binding domain, causing their dissociation from microtubules and increased …