The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …

Abstract Neuroligin-3 (NLGN3) is necessary and sufficient to promote glioma cell growth.
The recruitment of Gαi1/3 to the ligand-activated receptor tyrosine kinases (RTKs) is …

Melatonin is a neurohormone that is mainly secreted by the pineal gland. It coordinates the
work of the superior biological clock and consequently affects many processes in the human …

This brief review describes the association of the endogenous pineal melatonin rhythm with
the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new …

Alterations in myelin, the protective and insulating sheath surrounding axons, affect brain
function, as is evident in demyelinating diseases where the loss of myelin leads to cognitive …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

Glioma is the most prevalent malignant brain tumor in adults. The development of
engineered nanomaterials (ENMs) has led to the emergence of innovative therapeutic …

In crystal structures of melatonin MT 1 and MT 2 receptors, a lipophilic subpocket has been
characterized which accommodates the phenyl ring of the potent agonist 2-phenylmelatonin …