Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice

R Kano, T Kusano, R Takeda… - Journal of Applied …, 2024 - journals.physiology.org
Hydrogen peroxide (H2O2) is one of the key signaling factors regulating skeletal muscle
adaptation to muscle contractions. Eccentric (ECC) and concentric (CONC) contractions …

Age-related blunting of serial sarcomerogenesis and mechanical adaptations following 4 wk of maximal eccentric resistance training

A Hinks, MA Patterson, BS Njai… - Journal of Applied …, 2024 - journals.physiology.org
During aging, muscles undergo atrophy, which is partly accounted for by a loss of
sarcomeres in series. Serial sarcomere number (SSN) is associated with aspects of muscle …

Skeletal muscle adaptations following eccentric contractions are not mediated by keratin 18

MS Ganjayi, SW Frank, TA Krauss… - Journal of Applied …, 2024 - journals.physiology.org
The molecular mechanisms that drive muscle adaptations after eccentric exercise training
are multifaceted and likely impacted by age. Previous studies have reported that many …

Transcriptional and morphological responses following distinct muscle contraction protocols for Snell dwarf (Pit1dw/dw) mice

EP Rader, KA McKinstry, BA Baker - Physiological Reports, 2024 - Wiley Online Library
Abstract The Snell dwarf mouse (Pit1 dw/dw), an animal model of congenital combined
pituitary hormone deficiency, displays skeletal muscle weakness. While enhanced …