Mechanisms of blood–brain barrier protection by microbiota-derived short-chain fatty acids
E Fock, R Parnova - Cells, 2023 - mdpi.com
Impairment of the blood–brain barrier (BBB) integrity is implicated in the numerous
neurological disorders associated with neuroinflammation, neurodegeneration and aging. It …
neurological disorders associated with neuroinflammation, neurodegeneration and aging. It …
Functions of ROS in macrophages and antimicrobial immunity
M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment
The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …
Blood-brain barrier disruption by lipopolysaccharide and sepsis-associated encephalopathy
X Peng, Z Luo, S He, L Zhang, Y Li - Frontiers in cellular and infection …, 2021 - frontiersin.org
As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …
Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …
critical to neuronal function while simultaneously excluding neurotoxic substances from the …
Nanomaterial-based blood-brain-barrier (BBB) crossing strategies
Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …
Hypertension-induced cognitive impairment: from pathophysiology to public health
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …
Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases
Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
Claudin-5: gatekeeper of neurological function
Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …