Mechanosensory signaling in enterochromaffin cells and 5-HT release: potential implications for gut inflammation
Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response
to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility …
to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility …
Purinergic signalling in the gastrointestinal tract and related organs in health and disease
G Burnstock - Purinergic signalling, 2014 - Springer
Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
C Alcaino, KR Knutson, AJ Treichel… - Proceedings of the …, 2018 - National Acad Sciences
Enterochromaffin (EC) cells constitute the largest population of intestinal epithelial
enteroendocrine (EE) cells. EC cells are proposed to be specialized mechanosensory cells …
enteroendocrine (EE) cells. EC cells are proposed to be specialized mechanosensory cells …
Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces
F Wang, K Knutson, C Alcaino… - The Journal of …, 2017 - Wiley Online Library
Key points The gastrointestinal epithelial enterochromaffin (EC) cell synthesizes the vast
majority of the body's serotonin. As a specialized mechanosensor, the EC cell releases this …
majority of the body's serotonin. As a specialized mechanosensor, the EC cell releases this …
Mechanosensitive piezo channels in the gastrointestinal tract
Sensation of mechanical forces is critical for normal function of the gastrointestinal (GI) tract
and abnormalities in mechanosensation are linked to GI pathologies. In the GI tract there are …
and abnormalities in mechanosensation are linked to GI pathologies. In the GI tract there are …
Molecular signaling and dysfunction of the human reactive enteric glial cell phenotype: implications for GI infection, IBD, POI, neurological, motility, and GI disorders
Background Clinical observations or animal studies implicate enteric glial cells in motility
disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) …
disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) …
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
Enterochromaffin (EC) cells are the primary mechanosensors of the gastrointestinal (GI)
epithelium. In response to mechanical stimuliEC cells release serotonin (5 …
epithelium. In response to mechanical stimuliEC cells release serotonin (5 …
Purinergic signaling in gut inflammation: the role of connexins and pannexins
EF Diezmos, PP Bertrand, L Liu - Frontiers in Neuroscience, 2016 - frontiersin.org
Purinergic receptors play an important role in inflammation, and can be activated by ATP
released via pannexin channels and/or connexin hemichannels. The purinergic P2X7 …
released via pannexin channels and/or connexin hemichannels. The purinergic P2X7 …
Mechanical distension induces serotonin release from intestine as revealed by stretchable electrochemical sensing
YL Liu, Y Chen, WT Fan, P Cao, J Yan… - Angewandte Chemie …, 2020 - Wiley Online Library
The role of endogenous serotonin (5‐HT) in gastrointestinal motility is still highly
controversial. Although electrochemical techniques allow for direct and real‐time recording …
controversial. Although electrochemical techniques allow for direct and real‐time recording …
Potential for develo** purinergic drugs for gastrointestinal diseases
Treatments for inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), functional
dyspepsia, or motility disorders are not adequate, and purinergic drugs offer exciting new …
dyspepsia, or motility disorders are not adequate, and purinergic drugs offer exciting new …