Antituberculosis drugs: ten years of research

YL Janin - Bioorganic & medicinal chemistry, 2007 - Elsevier
Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Artificial intelligence approaches for rational drug design and discovery

W Duch, K Swaminathan… - Current pharmaceutical …, 2007 - ingentaconnect.com
Pattern recognition, machine learning and artificial intelligence approaches play an
increasingly important role in rational drug design, screening and identification of candidate …

Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

A Lilienkampf, J Mao, B Wan, Y Wang… - Journal of medicinal …, 2009 - ACS Publications
Tuberculosis (TB) remains as a global pandemic that is aggravated by a lack of health care,
the spread of HIV, and the emergence of multidrug-resistant TB (MDR-TB) and extensively …

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

S Ananthan, ER Faaleolea, RC Goldman, JV Hobrath… - Tuberculosis, 2009 - Elsevier
There is an urgent need for the discovery and development of new antitubercular agents that
target new biochemical pathways and treat drug resistant forms of the disease. One …

Direct synthesis of pyridines and quinolines by coupling of γ-amino-alcohols with secondary alcohols liberating H 2 catalyzed by ruthenium pincer complexes

D Srimani, Y Ben-David, D Milstein - Chemical Communications, 2013 - pubs.rsc.org
A novel, one-step synthesis of substituted pyridine-and quinoline-derivatives was achieved
by acceptorless dehydrogenative coupling of γ-aminoalcohols with secondary alcohols. The …

Pd-catalyzed amidations of aryl chlorides using monodentate biaryl phosphine ligands: A kinetic, computational, and synthetic investigation

T Ikawa, TE Barder, MR Biscoe… - Journal of the American …, 2007 - ACS Publications
We present results on the amidation of aryl halides and sulfonates utilizing a monodentate
biaryl phosphine-Pd catalyst. Our results are in accord with a previous report that suggests …

Auto‐Oxidative Coupling of Glycine Derivatives

C Huo, Y Yuan, M Wu, X Jia, X Wang… - Angewandte Chemie …, 2014 - Wiley Online Library
The unprecedented title reaction between glycine derivatives and indoles, as well as the
auto‐oxidative Povarov/aromatization tandem reaction of glycine derivatives with olefins are …

QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity

MN Gomes, RC Braga, EM Grzelak, BJ Neves… - European journal of …, 2017 - Elsevier
New anti-tuberculosis (anti-TB) drugs are urgently needed to battle drug-resistant
Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment …

QSAR studies on chalcones and flavonoids as anti-tuberculosis agents using genetic function approximation (GFA) method

PM Sivakumar, SKG Babu, D Mukesh - … and pharmaceutical bulletin, 2007 - jstage.jst.go.jp
Design of compounds having good anti-tubercular activity is gaining much importance in the
field of tuberculosis research due to reemergence of antibiotic resistance strains. In this …

Hydrophobicity-shake flasks, protein folding and drug discovery

A Sarkar, GE Kellogg - Current topics in medicinal chemistry, 2010 - ingentaconnect.com
Hydrophobic interactions are some of the most important interactions in nature. They are the
primary driving force in a number of phenomena. This is mostly an entropic effect and can …