Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass spectrometry reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

A new update of MALDI-TOF mass spectrometry in lipid research

KM Engel, P Prabutzki, J Leopold, A Nimptsch… - Progress in lipid …, 2022 - Elsevier
Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is an
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …

[HTML][HTML] Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research

S Rakusanova, O Fiehn, T Cajka - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …

Quantum chemistry calculations for metabolomics: Focus review

RM Borges, SM Colby, S Das, AS Edison… - Chemical …, 2021 - ACS Publications
A primary goal of metabolomics studies is to fully characterize the small-molecule
composition of complex biological and environmental samples. However, despite advances …

Nanospray desorption electrospray ionization (Nano-DESI) mass spectrometry imaging with high ion mobility resolution

LX Jiang, E Hernly, H Hu, RT Hilger… - Journal of the …, 2023 - ACS Publications
Untargeted separation of isomeric and isobaric species in mass spectrometry imaging (MSI)
is challenging. The combination of ion mobility spectrometry (IMS) with MSI has emerged as …

High-specificity imaging mass spectrometry

ME Colley, AB Esselman, CF Scott… - Annual Review of …, 2024 - annualreviews.org
Imaging mass spectrometry (IMS) enables highly multiplexed, untargeted tissue map** for
a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges …

Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers

SM Camunas-Alberca, M Moran-Garrido… - Frontiers in Molecular …, 2023 - frontiersin.org
It is increasingly evident that a more detailed molecular structure analysis of isomeric lipids
is critical to better understand their roles in biological processes. The occurrence of isomeric …

Applications and continued evolution of glycan imaging mass spectrometry

CT McDowell, X Lu, AS Mehta… - Mass spectrometry …, 2023 - Wiley Online Library
Glycosylation is an important posttranslational modifier of proteins and lipid conjugates
critical for the stability and function of these macromolecules. Particularly important are N …

The development and application of matrix assisted laser desorption electrospray ionization: The teenage years

M Caleb Bagley, KP Garrard… - Mass Spectrometry …, 2023 - Wiley Online Library
In the past 15 years, ambient ionization techniques have witnessed a significant incursion
into the field of mass spectrometry imaging, demonstrating their ability to provide …