[HTML][HTML] Ageing and Parkinson's disease: why is advancing age the biggest risk factor?
A Reeve, E Simcox, D Turnbull - Ageing research reviews, 2014 - Elsevier
As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …
disease, the health, social and economic impact resulting from Parkinson's disease will …
α-Synuclein in Parkinson's disease
L Stefanis - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …
Cell biology and pathophysiology of α-synuclein
α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease
The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain
AR Issa, J Sun, C Petitgas, A Mesquita, A Dulac… - Autophagy, 2018 - Taylor & Francis
The autophagy-lysosome pathway plays a fundamental role in the clearance of aggregated
proteins and protection against cellular stress and neurodegenerative conditions. Alterations …
proteins and protection against cellular stress and neurodegenerative conditions. Alterations …
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
Abstract α-Synuclein becomes misfolded and aggregated upon damage by various factors,
for example, by reactive oxygen species. These aggregated forms have been proposed to …
for example, by reactive oxygen species. These aggregated forms have been proposed to …
Copper pathology in vulnerable brain regions in Parkinson's disease
Synchrotron-based x-ray fluorescence microscopy, immunofluorescence, and Western
blotting were used to investigate changes in copper (Cu) and Cu-associated pathways in the …
blotting were used to investigate changes in copper (Cu) and Cu-associated pathways in the …
Intranasal administration of extracellular vesicles derived from human teeth stem cells improves motor symptoms and normalizes tyrosine hydroxylase expression in …
K Narbute, V Piļipenko, J Pupure… - Stem Cells …, 2019 - academic.oup.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
millions of people worldwide. At present, there is no effective cure for PD; treatments are …
millions of people worldwide. At present, there is no effective cure for PD; treatments are …
Drosophila melanogaster in the study of human neurodegeneration
F Hirth - CNS & Neurological Disorders-Drug Targets (Formerly …, 2010 - ingentaconnect.com
Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …
elderly people. The majority of the diseases are associated with pathogenic oligomers from …
Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
Mutations in the neuronal protein α-synuclein cause familial Parkinson disease.
Phosphorylation of α-synuclein at serine 129 is prominent in Parkinson disease and …
Phosphorylation of α-synuclein at serine 129 is prominent in Parkinson disease and …