Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …

Nanoscale or single-cell technologies are critical for biomedical applications. However,
current mass spectrometry (MS)-based proteomic approaches require samples comprising a …

In order to obtain a systems‐level understanding of a complex biological system, detailed
proteome information is essential. Despite great progress in proteomics technologies …

We report on the quantitative proteomic analysis of single mammalian cells. Fluorescence‐
activated cell sorting was employed to deposit cells into a newly developed nanodroplet …

Efficient and reproducible sample preparation is a prerequisite for any robust and sensitive
quantitative bottom-up proteomics workflow. Here, we performed an independent …

Metabolic reprogramming is linked to cancer cell growth and proliferation, metastasis, and
therapeutic resistance in a multitude of cancers. Targeting dysregulated metabolic pathways …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

Biological tissues exhibit complex spatial heterogeneity that directs the functions of
multicellular organisms. Quantifying protein expression is essential for elucidating …

Proteins regulate many cellular functions and analyzing the presence and abundance of
proteins in biological samples are central focuses in proteomics. The discovery and …