Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis
is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Controversy over the role of antioxidants in cancer has persisted for decades. Here, we
demonstrate that synthesis of the antioxidant glutathione (GSH), driven by GCLM, is required …

Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid
metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic …

Elevated hematocrit is associated with cardiovascular risk; however, the causality and
mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk …

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH …

Proper functioning of the ovary is critical to maintain fertility and overall health, and ovarian
function depends on the maintenance and normal development of ovarian follicles. This …

The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …