Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system
Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …
Molecular physiology of cardiac repolarization
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …
potential generation and propagation, followed by relaxation and a period of refractoriness …
DPPX antibody–associated encephalitis: main syndrome and antibody effects
Objective: To report the main syndrome of dipeptidyl-peptidase–like protein 6 (DPPX)
antibody–associated encephalitis, immunoglobulin G (IgG) subclass, and the antibody …
antibody–associated encephalitis, immunoglobulin G (IgG) subclass, and the antibody …
DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients
WO Tobin, VA Lennon, L Komorowski, C Probst… - Neurology, 2014 - neurology.org
Objective: To describe the detection frequency and clinical associations of immunoglobulin
G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of …
G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of …
Encephalitis and antibodies to dipeptidyl‐peptidase–like protein‐6, a subunit of Kv4. 2 potassium channels
Objective: To report a novel cell surface autoantigen of encephalitis that is a critical
regulatory subunit of the Kv4. 2 potassium channels. Methods: Four patients with …
regulatory subunit of the Kv4. 2 potassium channels. Methods: Four patients with …
[HTML][HTML] Stiff person syndrome spectrum disorders; more than meets the eye
Stiff person syndrome spectrum disorders (SPSD) are a group of rare neuroimmunological
disorders that often include painful spasms and rigidity. However, patients have highly …
disorders that often include painful spasms and rigidity. However, patients have highly …
Localization and targeting of voltage-dependent ion channels in mammalian central neurons
The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …
governed by the action of voltage-dependent ion channels. The localization of specific …
A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
KCNQ (KV7) potassium channels underlie subthreshold M-currents that stabilize the
neuronal resting potential and prevent repetitive firing of action potentials. Here, antibodies …
neuronal resting potential and prevent repetitive firing of action potentials. Here, antibodies …
The distribution and targeting of neuronal voltage-gated ion channels
HC Lai, LY Jan - Nature Reviews Neuroscience, 2006 - nature.com
Voltage-gated ion channels have to be at the right place in the right number to endow
individual neurons with their specific character. Their biophysical properties together with …
individual neurons with their specific character. Their biophysical properties together with …
Localization of voltage-gated ion channels in mammalian brain
The intrinsic electrical properties of neurons are shaped in large part by the action of voltage-
gated ion channels. Molecular cloning studies have revealed a large family of ion channel …
gated ion channels. Molecular cloning studies have revealed a large family of ion channel …